Early prediction of left ventricular function in streptokinase-treated acute myocardial infarction

David G. Fine, Avraham T. Weiss, Sima Welber, Dan Sapoznikov, Chaim Lotan, David Applebaum, Yosef Ben-David, Yonathan Hasin, Mervyn S. Gotsman

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

2 اقتباسات (Scopus)

ملخص

We administered 750,000 units of intravenous streptokinase to 121 consecutive patients experiencing their first acute myocardial infarction within 4 h of pain onset. The following information was collected: Hours between pain onset and streptokinase administration (TS), hours of pain after streptokinase administration (DP), initial and peak creatine phosphokinase levels (ICK and PCK), time to peak creatine phosphokinase, time to electrocardiographic ST segment resolution. Six days after the infarction, catheterization was performed to calculate ejection fraction, infarct-related regional ejection fraction, and dysfunction index. Data was analyzed using stepwise multiple regression. In patients experiencing anterior infarctions, the following equation was obtained predicting the ejection fraction (EF) with a correlation coefficient of 0.86: EF = 69 0.0050(PCK) 3.7(TS) 1.8(DP). In anterior infarctions the infarct-related ejection fraction and dysfunction index were similarly predictable. We were slightly less accurate in forecasting the outcome of inferior infarctions. The outcome of intravenous streptokinase therapy can be predicted early in the evolution of acute myocardial infarction using routinely available information.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)170-176
عدد الصفحات7
دوريةCardiology
مستوى الصوت75
رقم الإصدار3
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 1988
منشور خارجيًانعم

بصمة

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