Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel

R. Ben-Ami; G. Rahav; H. Elinav; I. Kassis; I. Shalit; T. Gottesman; O. Megged; M. Weinberger; P. Ciobotaro; P. Shitrit; G. Weber; A. Paz; D. Miron; I. Oren; J. Bishara; C. Block; N. Keller; D. P. Kontoyiannis; M. Giladi

doi:10.1111/1469-0691.12004

Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel

R. Ben-Ami, G. Rahav, H. Elinav, I. Kassis, I. Shalit, T. Gottesman, O. Megged, M. Weinberger, P. Ciobotaro, P. Shitrit, G. Weber, A. Paz, D. Miron, I. Oren, J. Bishara, C. Block, N. Keller, D. P. Kontoyiannis, M. Giladi

نتاج البحث: نشر في مجلة › مقالة › مراجعة النظراء

19 اقتباسات (Scopus)

ملخص

The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with >600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting.

اللغة الأصلية	الإنجليزيّة
الصفحات (من إلى)	752-756
عدد الصفحات	5
دورية	Clinical Microbiology and Infection
مستوى الصوت	19
رقم الإصدار	8
المعرِّفات الرقمية للأشياء	https://doi.org/10.1111/1469-0691.12004
حالة النشر	نُشِر - أغسطس 2013
منشور خارجيًا	نعم

الوصول إلى المستند

10.1111/1469-0691.12004

الملفات والروابط الأخرى

Link to publication in Scopus

قم بذكر هذا

Ben-Ami, R., Rahav, G., Elinav, H., Kassis, I., Shalit, I., Gottesman, T., Megged, O., Weinberger, M., Ciobotaro, P., Shitrit, P., Weber, G., Paz, A., Miron, D., Oren, I., Bishara, J., Block, C., Keller, N., Kontoyiannis, D. P., & Giladi, M. (2013). Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel. Clinical Microbiology and Infection, 19(8), 752-756. https://doi.org/10.1111/1469-0691.12004

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title = "Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel",

abstract = "The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with >600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting.",

keywords = "Candidaemia, Drug resistance, Epidemiology, Fluconazole",

author = "R. Ben-Ami and G. Rahav and H. Elinav and I. Kassis and I. Shalit and T. Gottesman and O. Megged and M. Weinberger and P. Ciobotaro and P. Shitrit and G. Weber and A. Paz and D. Miron and I. Oren and J. Bishara and C. Block and N. Keller and Kontoyiannis, {D. P.} and M. Giladi",

note = "Funding Information: This work was funded in part by a grant from Merck Sharp & Dohme Ltd, Israel and by the Israeli Society for Infectious Diseases. ",

year = "2013",

month = aug,

doi = "10.1111/1469-0691.12004",

language = "אנגלית",

volume = "19",

pages = "752--756",

journal = "Clinical Microbiology and Infection",

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number = "8",

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Ben-Ami, R, Rahav, G, Elinav, H, Kassis, I, Shalit, I, Gottesman, T, Megged, O, Weinberger, M, Ciobotaro, P, Shitrit, P, Weber, G, Paz, A, Miron, D, Oren, I, Bishara, J, Block, C, Keller, N, Kontoyiannis, DP & Giladi, M 2013, 'Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel', Clinical Microbiology and Infection, المجلد 19, رقم 8, الصفحات 752-756. https://doi.org/10.1111/1469-0691.12004

TY - JOUR

T1 - Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel

AU - Ben-Ami, R.

AU - Rahav, G.

AU - Elinav, H.

AU - Kassis, I.

AU - Shalit, I.

AU - Gottesman, T.

AU - Megged, O.

AU - Weinberger, M.

AU - Ciobotaro, P.

AU - Shitrit, P.

AU - Weber, G.

AU - Paz, A.

AU - Miron, D.

AU - Oren, I.

AU - Bishara, J.

AU - Block, C.

AU - Keller, N.

AU - Kontoyiannis, D. P.

AU - Giladi, M.

N1 - Funding Information: This work was funded in part by a grant from Merck Sharp & Dohme Ltd, Israel and by the Israeli Society for Infectious Diseases.

PY - 2013/8

Y1 - 2013/8

N2 - The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with >600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting.

AB - The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with >600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting.

KW - Candidaemia

KW - Drug resistance

KW - Epidemiology

KW - Fluconazole

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U2 - 10.1111/1469-0691.12004

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AN - SCOPUS:84880512733

SN - 1198-743X

VL - 19

SP - 752

EP - 756

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 8

ER -

Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel

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