Detection of Human Growth Hormone (hGH) via Cyclodextrin-Promoted Fluorescence Modulation

The ability to detect human growth hormone (hGH) via sensitive, selective, and easy-to-use methods is a high priority research area from a variety of public health, law enforcement, and scientific objectives. Reported herein is the use of cyclodextrin-promoted fluorescence modulation of a high-quantum yield BODIPY fluorophore in the presence of low concentrations of hGH, leading to a system that can detect hGH in concentrations as low as 0.279 µM and with a 96% accuracy in distinguishing different hGH concentrations.