TY - JOUR
T1 - Data on peptidyl platform-based anticancer drug synthesis and triton-x-based micellar clusters (MCs) self-assembly peculiarities for enhanced solubilization, encapsulation of hydrophobic compounds and their interaction with HeLa cells
AU - Solomonov, Alexey V.
AU - Marfin, Yuriy S.
AU - Rumyantsev, Evgeniy V.
AU - Ragozin, Elena
AU - Zahavi, Talia Shekhter
AU - Gellerman, Gary
AU - Tesler, Alexander B.
AU - Muench, Falk
AU - Kumagai, Akiko
AU - Miyawaki, Atsushi
N1 - Publisher Copyright:
© 2019 The Authors
PY - 2019/8
Y1 - 2019/8
N2 - The data presented here refer to a research article entitled “Self-Assembled Micellar Clusters Based on Triton-X-family Surfactants for Enhanced Solubilization, Encapsulation, Proteins Permeability Control, and Anticancer Drug Delivery” Solomonov et al., 2019. The present article provides the General Procedure for clusterization of Triton-X-based micelles and the effect of (i) metal ion, surfactant, and chelator concentration on the developed clusters formation, (ii) surfactant-chelator relation change, (iii) metal ion-micelles concertation ratio variation, (iv) metal ion replacement, (v) solvent replacement, (vi) kinetics of clusters formation, (vii) hydrophobic fluorescent dye (Coumarin 6) solubilization in aqueous MCs media, (viii) novel anticancer peptidyl drug synthesis and characterization and (ix) the viability of HeLa cells with and without the presence of drug-free Triton-X-based family MCs. These data provide additional insights useful for understanding all aspects of the micellar clusters formation, optimization, and control.
AB - The data presented here refer to a research article entitled “Self-Assembled Micellar Clusters Based on Triton-X-family Surfactants for Enhanced Solubilization, Encapsulation, Proteins Permeability Control, and Anticancer Drug Delivery” Solomonov et al., 2019. The present article provides the General Procedure for clusterization of Triton-X-based micelles and the effect of (i) metal ion, surfactant, and chelator concentration on the developed clusters formation, (ii) surfactant-chelator relation change, (iii) metal ion-micelles concertation ratio variation, (iv) metal ion replacement, (v) solvent replacement, (vi) kinetics of clusters formation, (vii) hydrophobic fluorescent dye (Coumarin 6) solubilization in aqueous MCs media, (viii) novel anticancer peptidyl drug synthesis and characterization and (ix) the viability of HeLa cells with and without the presence of drug-free Triton-X-based family MCs. These data provide additional insights useful for understanding all aspects of the micellar clusters formation, optimization, and control.
KW - Anticancer drug synthesis
KW - Encapsulation
KW - Fluorescence enhancement
KW - Micellar clusters
KW - Self-assembly
KW - Surfactants
KW - Triton-X
UR - http://www.scopus.com/inward/record.url?scp=85066610593&partnerID=8YFLogxK
U2 - 10.1016/j.dib.2019.104052
DO - 10.1016/j.dib.2019.104052
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AN - SCOPUS:85066610593
SN - 2352-3409
VL - 25
JO - Data in Brief
JF - Data in Brief
M1 - 104052
ER -