TY - JOUR
T1 - Complications of retroperitoneal lymph node dissection in testicular cancer
T2 - Primary and post-chemotherapy
AU - Baniel, Jack
AU - Sella, Avishay
PY - 1999/12
Y1 - 1999/12
N2 - Retroperitoneal lymph node dissection (RPLND) is utilized in low-stage testis cancer as a primary diagnostic and therapeutic procedure. In the post- chemotherapy setting, it serves as an adjuvant procedure to resect residual tumor. Primary RPLND entails minimal resection of lymphatic tissue in the retroperitoneum; the complications are minor and insignificant. Wound infection is the main complication, affecting less than 5% of patients. Atelectasis and small bowel obstruction may occur in less than 2% of patients. In post-chemotherapy RPLND, the template and the surgical challenge are much larger. Extensive tumor size, difficult location, adherence to major vessels, and vital structures, together with inferior pre-operative status, are probably the main reasons for complications. The overall complication rate is 20% to 35% and mortality is 0.8% to 1%. Pulmonary insufficiency secondary to bleomycin-induced interstitial fibrosis is the cause of the most severe side effects and mortality in these operations. Chylous ascites may occur, especially where resection of the inferior vena cava is necessary. Other complications occur to a lesser extent. A summary of all complications is presented and measures to avoid or manage them are depicted.
AB - Retroperitoneal lymph node dissection (RPLND) is utilized in low-stage testis cancer as a primary diagnostic and therapeutic procedure. In the post- chemotherapy setting, it serves as an adjuvant procedure to resect residual tumor. Primary RPLND entails minimal resection of lymphatic tissue in the retroperitoneum; the complications are minor and insignificant. Wound infection is the main complication, affecting less than 5% of patients. Atelectasis and small bowel obstruction may occur in less than 2% of patients. In post-chemotherapy RPLND, the template and the surgical challenge are much larger. Extensive tumor size, difficult location, adherence to major vessels, and vital structures, together with inferior pre-operative status, are probably the main reasons for complications. The overall complication rate is 20% to 35% and mortality is 0.8% to 1%. Pulmonary insufficiency secondary to bleomycin-induced interstitial fibrosis is the cause of the most severe side effects and mortality in these operations. Chylous ascites may occur, especially where resection of the inferior vena cava is necessary. Other complications occur to a lesser extent. A summary of all complications is presented and measures to avoid or manage them are depicted.
KW - Bleomycin
KW - Combined antineoplastic agents
KW - Combined modality therapy
KW - General anesthesia
KW - Intestinal obstruction
KW - Lymph node excision
KW - Lymphocele/diagnosis
KW - Male infertility
KW - Oxygen inhalation therapy
KW - Postoperative complications
KW - Retroperitoneal space
KW - Testicular neoplasms
KW - Wound infection
UR - http://www.scopus.com/inward/record.url?scp=0032763863&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1098-2388(199912)17:4<263::AID-SSU7>3.0.CO;2-6
DO - 10.1002/(SICI)1098-2388(199912)17:4<263::AID-SSU7>3.0.CO;2-6
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C2 - 10588855
AN - SCOPUS:0032763863
SN - 8756-0437
VL - 17
SP - 263
EP - 267
JO - Seminars in Surgical Oncology
JF - Seminars in Surgical Oncology
IS - 4
ER -