TY - JOUR
T1 - Complex segregation analysis of two principal components derived from horizontal and vertical head size traits
AU - Ermakov, Sergey
AU - Kobyliansky, Eugene
AU - Livshits, Gregory
N1 - Funding Information:
The study was performed in partial fulfilment of the doctoral degree requirements of Sergey Ermakov. This research was supported by grant 1042/04 from Israel Science Foundation. We thank Dr Ida Malkin (Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University) for her assistance and advice. We are also grateful to two anonymous reviewers for the constructive comments on the early version of the paper.
PY - 2006/9
Y1 - 2006/9
N2 - Background: There is a wealth of publications establishing the involvement of genetic factors in the determination of inter-individual variability of head size traits. However, little is known about the mode of inheritance of craniofacial traits in the healthy population. Aim: The aims of this study were to investigate the mode of inheritance of horizontal (HOC) and vertical (VEC) components of head dimensions, and to test the hypothesis of a common major gene for these traits. Subjects and methods: The study was conducted on 1406 individuals belonging to 357 pedigrees. Univariate and bivariate complex segregation analyses were conducted on two principal components, HOC and VEC, extracted from 10 original head traits. Results: The hypothesis of Mendelian transmission was accepted in both studied traits. The inferred major genes explained 54.0% and 45.6% of HOC and VEC variance, adjusted for covariates. For both traits an additive mode of major gene alleles interaction was suggested. No positive evidence for a common major gene for both HOC and VEC was obtained. Conclusion: We conclude that head size in horizontal and vertical dimensions is determined by two different major genes together with modest and minor effect genes, the latter being partly shared by HOC and VEC.
AB - Background: There is a wealth of publications establishing the involvement of genetic factors in the determination of inter-individual variability of head size traits. However, little is known about the mode of inheritance of craniofacial traits in the healthy population. Aim: The aims of this study were to investigate the mode of inheritance of horizontal (HOC) and vertical (VEC) components of head dimensions, and to test the hypothesis of a common major gene for these traits. Subjects and methods: The study was conducted on 1406 individuals belonging to 357 pedigrees. Univariate and bivariate complex segregation analyses were conducted on two principal components, HOC and VEC, extracted from 10 original head traits. Results: The hypothesis of Mendelian transmission was accepted in both studied traits. The inferred major genes explained 54.0% and 45.6% of HOC and VEC variance, adjusted for covariates. For both traits an additive mode of major gene alleles interaction was suggested. No positive evidence for a common major gene for both HOC and VEC was obtained. Conclusion: We conclude that head size in horizontal and vertical dimensions is determined by two different major genes together with modest and minor effect genes, the latter being partly shared by HOC and VEC.
KW - Craniofacial measurements
KW - Major gene
KW - Univariate and bivariate complex segregation analysis
UR - https://www.scopus.com/pages/publications/33847735133
U2 - 10.1080/03014460600931046
DO - 10.1080/03014460600931046
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 17381053
AN - SCOPUS:33847735133
SN - 0301-4460
VL - 33
SP - 546
EP - 556
JO - Annals of Human Biology
JF - Annals of Human Biology
IS - 5-6
ER -