CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency

Keyphrases

• Binding Affinity 100%
• HU-308 100%
• Biological Potency 100%
• CB2 Cannabinoid Receptor 100%
• Cannabinoid Receptor Agonists 100%
• Inflammation 33%
• Am(III) 16%
• Mouse Model 16%
• Binding Site 16%
• Culture System 16%
• Osteoblast Proliferation 16%
• Cannabinoid Receptor 1 (CB1R) 16%
• Protective Mechanism 16%
• Δ9-tetrahydrocannabinol (Δ9-THC) 16%
• CB1 Receptor 16%
• Pharmacological Activation 16%
• Age-related Bone Loss 16%
• Anti-osteoporotic 16%
• Cannabinoid Receptor 2 16%
• Endogenous Cannabinoid 16%
• Radioligand 16%
• Molecular Modelling Analysis 16%
• CB2 Receptor 16%
• Targeting Ligands 16%
• Affinity Difference 16%
• Binding Studies 16%
• CB2 Agonist 16%
• Differentiation Culture 16%
• Binding Conformation 16%
• CP55940 16%
• Osteoclast Differentiation 16%
• Ovariectomy-induced Bone Loss 16%

Biochemistry, Genetics and Molecular Biology

• Binding Affinity 100%
• Enantiomer 100%
• Receptor Agonists 100%
• Cannabinoid Receptor 100%
• Osteolysis 66%
• Osteoblast 33%
• Cyclic Adenosine Monophosphate 33%
• Mouse Model 33%
• Osteoclastogenesis 33%
• Binding Site 33%
• Conformation 33%
• Molecular Model 33%
• Agonist 33%
• Tetrahydrocannabinol 33%
• Binding Study 33%
• Psychoactive Plant 33%
• Radioligand 33%
• Cannabinoid 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Sulfur 35 100%
• Cannabinoid 2 Receptor 100%
• Cannabinoid 1 Receptor 100%
• Cannabinoid 2 Receptor Agonist 100%
• Ovariectomy-Induced Osteoporosis 50%
• Inflammation 50%
• Binding Site 50%
• Endocannabinoid 50%
• Mouse Model 50%
• Tetrahydrocannabinol 50%
• Otitis 50%
• Radioligand 50%
• Psychoactive Plant 50%