Antimicrobial Peptides against Multidrug-Resistant Pseudomonas aeruginosa Biofilm from Cystic Fibrosis Patients

Daniel Ben Hur, Gal Kapach, Naiem Ahmad Wani, Edo Kiper, Moshe Ashkenazi, Gill Smollan, Natan Keller, Ori Efrati, Yechiel Shai

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

23 اقتباسات (Scopus)

ملخص

Lung infection is the leading cause of morbidity and mortality in cystic fibrosis (CF) patients and is mainly dominated by Pseudomonas aeruginosa. Treatment of CF-associated lung infections is problematic because the drugs are vulnerable to multidrug-resistant pathogens, many of which are major biofilm producers like P. aeruginosa. Antimicrobial peptides (AMPs) are essential components in all life forms and exhibit antimicrobial activity. Here we investigated a series of AMPs (d,l-K6L9), each composed of six lysines and nine leucines but differing in their sequence composed of l- and d-amino acids. The d,l-K6L9 peptides showed antimicrobial and antibiofilm activities against P. aeruginosa from CF patients. Furthermore, the data revealed that the d,l-K6L9 peptides are stable and resistant to degradation by CF sputum proteases and maintain their activity in a CF sputum environment. Additionally, the d,l-K6L9 peptides do not induce bacterial resistance. Overall, these findings should assist in the future development of alternative treatments against resistant bacterial biofilms.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)9050-9062
عدد الصفحات13
دوريةJournal of Medicinal Chemistry
مستوى الصوت65
رقم الإصدار13
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 14 يوليو 2022

بصمة

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