TY - JOUR
T1 - Angiographic findings in the coronary arteries after thrombolysis in acute myocardial infarction
AU - Gotsman, Mervyn
AU - Rosenheck, Shimon
AU - Nassar, Hisham
AU - Welber, Sima
AU - Sapoznikov, Dan
AU - Mosseri, Morris
AU - Weiss, Avraham
AU - Lotan, Chaim
AU - Rozenman, Yoseph
N1 - Funding Information:
From the Cardiac Department, Hadassah University Hospital, Jerusalem, Israel. This study was supported by a grant from the Israeli-German Binational Research Foundation, Jerusalem, Israel. Manuscript received January 22, 1992; re.vised manuscript received and accepted May 21,1992.
PY - 1992/9/15
Y1 - 1992/9/15
N2 - The angiographic appearance of the coronary arteries was examined in 308 patients with acute myocardial infarction (AMI) who received highdose intravenous thrombolytic therapy. Coronary angiography was performed on day 7 after admission to the hospital. Patients had an average of 2.4 discrete arterial narrowings or obstructions. The narrowings were proximal and related to bifurcations. Four fifths of the culprit arteries were patent; 104 (34%) had a ruptured plaque, 22 (7%) had an ulcerated plaque, and in 190 (62%) the lesions were eccentric. Patients differed from a comparable, previously studied, control series of 302 patients with chronic stable angina pectoris who had more extensive disease. They had 5.7 narrowings/patient, also located proximally and at bifurcations, but more widely distributed in the coronary tree. Patients with AMI who are suitable for thrombolysis have a unique coronary angiographic picture. The data confirm that AMI is caused by sudden rupture of a localized atheromatous plaque that initiates an obstructive thrombotic cascade.
AB - The angiographic appearance of the coronary arteries was examined in 308 patients with acute myocardial infarction (AMI) who received highdose intravenous thrombolytic therapy. Coronary angiography was performed on day 7 after admission to the hospital. Patients had an average of 2.4 discrete arterial narrowings or obstructions. The narrowings were proximal and related to bifurcations. Four fifths of the culprit arteries were patent; 104 (34%) had a ruptured plaque, 22 (7%) had an ulcerated plaque, and in 190 (62%) the lesions were eccentric. Patients differed from a comparable, previously studied, control series of 302 patients with chronic stable angina pectoris who had more extensive disease. They had 5.7 narrowings/patient, also located proximally and at bifurcations, but more widely distributed in the coronary tree. Patients with AMI who are suitable for thrombolysis have a unique coronary angiographic picture. The data confirm that AMI is caused by sudden rupture of a localized atheromatous plaque that initiates an obstructive thrombotic cascade.
UR - http://www.scopus.com/inward/record.url?scp=0026756035&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(92)90547-C
DO - 10.1016/0002-9149(92)90547-C
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C2 - 1519520
AN - SCOPUS:0026756035
SN - 0002-9149
VL - 70
SP - 715
EP - 723
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 7
ER -