Analysis of the Leishmania donovani transcriptome reveals an ordered progression of transient and permanent changes in gene expression during differentiation

Keyphrases

• Amastigote 100%
• Cell Motility 33%
• Changes in Abundance 33%
• Changes in Gene Expression 100%
• Differentiation Process 66%
• Downregulated Genes 33%
• Expression Profiling 33%
• Gene Expression 33%
• Genome-scale 33%
• Heat Shock Proteins 33%
• Histone Deacetylase 1 (HDAC1) 33%
• Host-free 66%
• Intracellular Amastigotes 33%
• Kala-azar 33%
• Leishmania Donovani 100%
• Macrophages 33%
• Metabolism 33%
• Microarray 33%
• Morphological Differentiation 33%
• MRNA Abundance 66%
• MRNA Turnover 33%
• Non-coding RNA (ncRNA) 33%
• Phagolysosome 33%
• Promastigote 100%
• Protein Kinase 33%
• Protein Phosphatase 33%
• Protein Turnover 33%
• Protozoan Parasites 33%
• Rapid Differentiation 33%
• Ribosomal RNA 33%
• RNA-binding Protein 33%
• Signal Transduction 33%
• Signaling Molecules 33%
• Small nucleolar RNA (snoRNA) 33%
• Substantial Change 33%
• Surface Proteins 33%
• Telomere 33%
• Transcriptome 100%
• Transporter Proteins 33%
• UCHL1 33%

Immunology and Microbiology

• Amastigote 100%
• Cell Migration 25%
• Cell Motility 25%
• Downregulation 25%
• Gene Expression 100%
• Heat Shock 25%
• Histone 25%
• Leishmania donovani 100%
• Macrophage 25%
• Morphology 25%
• Phagolysosome 25%
• Promastigote 75%
• Protein RNA Binding 25%
• Protozoa 25%
• Signal Transduction 25%
• Telomere 25%
• Transcriptome 100%
• Ubiquitins 25%
• Upregulation 25%
• Visceral Leishmaniasis 25%

Biochemistry, Genetics and Molecular Biology

• Deubiquitylating Enzyme 25%