ملخص
Since low serum l-Arginine (Arg) and high asymmetric dimethylarginine (ADMA) can predict microvascular complications in type 2 diabetes mellitus (T2DM), we tested whether Arg and ADMA are affected by diet and physical activity in overweight/obese and T2DM subjects. We tested the effects on serum Arg and ADMA of single loads of dextrose, protein, fat, or alcohol (∼300 calories each); one episode of physical exercise; and 12 weeks of standard lifestyle modification (dietary and physical activity counseling). Alcohol drink was followed by ∼30% lowering in Arg. Arg and ADMA increased after a protein load but remained stable after glucose or fat load or 30 min of treadmill walk. Following 12 weeks of lifestyle modification, ADMA declined only in subjects achieving weight loss >5%. In conclusion, alcohol is a previously unrecognized acute suppressor of serum Arg. Lifestyle modification lowers ADMA in subjects who achieve weight loss >5%. Clinical Trial Registration Number: NCT04406402.
اللغة الأصلية | الإنجليزيّة |
---|---|
الصفحات (من إلى) | 675-682 |
عدد الصفحات | 8 |
دورية | Journal of Medicinal Food |
مستوى الصوت | 25 |
رقم الإصدار | 6 |
المعرِّفات الرقمية للأشياء | |
حالة النشر | نُشِر - 1 يونيو 2022 |