Acylation of 5-phenyl-2-(fur-2-yl)oxazole

The ability of 5-phenyl-2-(fur-2-yl)oxazole to undergo acetylation and formylation is considered. It was established by x-ray structure analysis that electrophilic substitution proceeds at the position 5 of the furan ring. The direction of the reactions is analyzed from positions of the energy preference of transition states.