ملخص
We describe 7 cases of abnormal karyotypes involving chromosomes Y and 15 in Ethiopian Beta Israel patients: 46,XX, der(15)t(Y;15)(q12;p12) and 46,XY,der(15)t(Y;15)(q12;p12). Six cases were incidentally found in amniocentesis performed for various indications; the indication for karyotyping in 1 case was recurrent abortions. To the best of our knowledge, this is the first report of this translocation in a specific ethnic group. We conclude that the derivative chromosome 15 with chromosome Y is probably a normal variant in Ethiopian Beta Israel occurring at an estimated frequency of 4/74 (5.4%). The prenatal diagnosis of this translocation in this population probably does not require further parental testing.
اللغة الأصلية | الإنجليزيّة |
---|---|
الصفحات (من إلى) | 171-174 |
عدد الصفحات | 4 |
دورية | Cytogenetic and Genome Research |
مستوى الصوت | 136 |
رقم الإصدار | 3 |
المعرِّفات الرقمية للأشياء | |
حالة النشر | نُشِر - أبريل 2012 |
منشور خارجيًا | نعم |