A novel VIP responsive gene: Activity dependent neuroprotective protein

I. Gozes; R. Zamostiano; A. Pinhasov; M. Bassan; E. Giladi; R. A. Steingart; D. E. Brenneman

doi:10.1111/j.1749-6632.2000.tb06957.x

A novel VIP responsive gene: Activity dependent neuroprotective protein

I. Gozes
, R. Zamostiano
, A. Pinhasov
, M. Bassan
, E. Giladi
, R. A. Steingart
, D. E. Brenneman

نتاج البحث: نشر في مجلة › مقالة › مراجعة النظراء

39 اقتباسات (Scopus)

ملخص

Activity dependent neuroprotective protein (ADNP, 828 amino acids, pI 5.99) is a glial-derived protein that contains a femtomolar active neuroprotective peptide, NAPVSIPQ (NAP). VIP induces a two- to threefold increase in ADNP mRNA in astrocytes, suggesting that ADNP is a VIP-responsive gene. ADNP is widely distributed in the mouse hippocampus, cerebellum, and cerebral cortex. VIP has been shown to possess neuroprotective activity that may be exerted through the activation of glial proteins. We suggest that ADNP may be part of the VIP protection pathway through the femtomolaracting NAP and through putative interaction with other macromolecules.

اللغة الأصلية	الإنجليزيّة
الصفحات (من إلى)	115-118
عدد الصفحات	4
دورية	Annals of the New York Academy of Sciences
مستوى الصوت	921
المعرِّفات الرقمية للأشياء	https://doi.org/10.1111/j.1749-6632.2000.tb06957.x
حالة النشر	نُشِر - 2000
منشور خارجيًا	نعم

الوصول إلى المستند

10.1111/j.1749-6632.2000.tb06957.x

الملفات والروابط الأخرى

Link to publication in Scopus

قم بذكر هذا

@article{727086b10b3c488382868b68ba9ed478,

title = "A novel VIP responsive gene: Activity dependent neuroprotective protein",

abstract = "Activity dependent neuroprotective protein (ADNP, 828 amino acids, pI 5.99) is a glial-derived protein that contains a femtomolar active neuroprotective peptide, NAPVSIPQ (NAP). VIP induces a two- to threefold increase in ADNP mRNA in astrocytes, suggesting that ADNP is a VIP-responsive gene. ADNP is widely distributed in the mouse hippocampus, cerebellum, and cerebral cortex. VIP has been shown to possess neuroprotective activity that may be exerted through the activation of glial proteins. We suggest that ADNP may be part of the VIP protection pathway through the femtomolaracting NAP and through putative interaction with other macromolecules.",

author = "I. Gozes and R. Zamostiano and A. Pinhasov and M. Bassan and E. Giladi and Steingart, \{R. A.\} and Brenneman, \{D. E.\}",

year = "2000",

doi = "10.1111/j.1749-6632.2000.tb06957.x",

language = "אנגלית",

volume = "921",

pages = "115--118",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - A novel VIP responsive gene

T2 - Activity dependent neuroprotective protein

AU - Gozes, I.

AU - Zamostiano, R.

AU - Pinhasov, A.

AU - Bassan, M.

AU - Giladi, E.

AU - Steingart, R. A.

AU - Brenneman, D. E.

PY - 2000

Y1 - 2000

N2 - Activity dependent neuroprotective protein (ADNP, 828 amino acids, pI 5.99) is a glial-derived protein that contains a femtomolar active neuroprotective peptide, NAPVSIPQ (NAP). VIP induces a two- to threefold increase in ADNP mRNA in astrocytes, suggesting that ADNP is a VIP-responsive gene. ADNP is widely distributed in the mouse hippocampus, cerebellum, and cerebral cortex. VIP has been shown to possess neuroprotective activity that may be exerted through the activation of glial proteins. We suggest that ADNP may be part of the VIP protection pathway through the femtomolaracting NAP and through putative interaction with other macromolecules.

AB - Activity dependent neuroprotective protein (ADNP, 828 amino acids, pI 5.99) is a glial-derived protein that contains a femtomolar active neuroprotective peptide, NAPVSIPQ (NAP). VIP induces a two- to threefold increase in ADNP mRNA in astrocytes, suggesting that ADNP is a VIP-responsive gene. ADNP is widely distributed in the mouse hippocampus, cerebellum, and cerebral cortex. VIP has been shown to possess neuroprotective activity that may be exerted through the activation of glial proteins. We suggest that ADNP may be part of the VIP protection pathway through the femtomolaracting NAP and through putative interaction with other macromolecules.

UR - https://www.scopus.com/pages/publications/0034508629

U2 - 10.1111/j.1749-6632.2000.tb06957.x

DO - 10.1111/j.1749-6632.2000.tb06957.x

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C2 - 11193814

AN - SCOPUS:0034508629

SN - 0077-8923

VL - 921

SP - 115

EP - 118

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

A novel VIP responsive gene: Activity dependent neuroprotective protein

ملخص

الوصول إلى المستند

الملفات والروابط الأخرى

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