A novel index for expressing exposure of the infant to drugs in breast milk.

S. Ito, G. Koren

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

53 اقتباسات (Scopus)

ملخص

1. We present a novel index for expressing the exposure of the infant to drugs in breast milk, which unifies two independent factors: a pharmacokinetic parameter, drug clearance, and a physiochemical parameter, i.e. milk‐to‐maternal plasma drug concentration ratio (M/P ratio). 2. During breast‐feeding by a woman receiving therapeutic doses of a drug at steady state this index is given by: Exposure index = A × (M/P ratio)/CLI where A is a coefficient (10 ml kg‐1 min‐1) and CLI is drug clearance in the infant (ml kg‐1 min‐1). 3. This equation indicates a hyperbolic relationship between drug clearance and the exposure level of the breast‐fed infant at a given M/P ratio of drug, emphasizing the importance of drug clearance as a determinant of infant exposure. 1994 The British Pharmacological Society

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)99-102
عدد الصفحات4
دوريةBritish Journal of Clinical Pharmacology
مستوى الصوت38
رقم الإصدار2
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - أغسطس 1994
منشور خارجيًانعم

بصمة

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